Publications - UMRS 1160

Tuesday 5 May 2015

Team 1 : “Lymphocyte differentiation and homeostasis in allo- and autoimmunity” (Team leader, A. Toubert)


  1. Moins-Teisserenc, H., M. Daubord, E. Clave, C. Douay, J. Felix, A. Marie-Cardine, C. Ram-Wolff, G. Maki, K. Beldjord, L. Homyrda, L. Michel, A. Bensussan, A. Toubert, and M. Bagot. 2015. CD158k Is a Reliable Marker for Diagnosis of Sezary Syndrome and Reveals an Unprecedented Heterogeneity of Circulating Malignant Cells. The Journal of investigative dermatology 135: 247-257.
  2. Itzykson, R., M. Robin, H. Moins-Teisserenc, M. Delord, M. Busson, A. Xhaard, F. S. de Fontebrune, R. Peffault de Latour, A. Toubert, and G. Socie. 2015. Cytomegalovirus shapes long-term immune reconstitution after allogeneic stem cell transplantation. Haematologica 100: 114-123.
  3. Yap, M., F. Boeffard, E. Clave, A. Pallier, R. Danger, M. Giral, J. Dantal, Y. Foucher, C. Guillot-Gueguen, A. Toubert, J. P. Soulillou, S. Brouard, and N. Degauque. 2014. Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction. Journal of the American Society of Nephrology : JASN 25: 1856-1868.
  4. Xhaard, A., H. Moins-Teisserenc, M. Busson, M. Robin, P. Ribaud, N. Dhedin, S. Abbes, M. Carmagnat, V. D. Kheav, G. Maki, R. Peffault de Latour, A. Toubert, and G. Socie. 2014. Reconstitution of regulatory T-cell subsets after allogeneic hematopoietic SCT. Bone marrow transplantation 49: 1089-1092.
  5. Servais, S., E. Lengline, R. Porcher, M. Carmagnat, R. Peffault de Latour, M. Robin, F. Sicre de Fontebrune, E. Clave, G. Maki, C. Granier, A. Xhaard, N. Dhedin, J. M. Molina, A. Toubert, H. Moins-Teisserenc, and G. Socie. 2014. Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20: 507-517.
  6. Kheav, V. D., M. Busson, C. Scieux, R. Peffault de Latour, G. Maki, P. Haas, M. C. Mazeron, M. Carmagnat, E. Masson, A. Xhaard, M. Robin, P. Ribaud, N. Dulphy, P. Loiseau, D. Charron, G. Socie, A. Toubert, and H. Moins-Teisserenc. 2014. Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation. Haematologica 99: 1860-1867.
  7. Khaznadar, Z., G. Henry, N. Setterblad, S. Agaugue, E. Raffoux, N. Boissel, H. Dombret, A. Toubert, and N. Dulphy. 2014. Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse. European journal of immunology 44: 3068-3080.
  8. Glauzy, S., J. Soret, I. Fournier, C. Douay, H. Moins-Teisserenc, R. Peffault de Latour, G. Maki, M. Robin, G. Socie, A. Toubert, and E. Clave. 2014. Impact of acute and chronic graft-versus-host disease on human B-cell generation and replication. Blood 124: 2459-2462.
  9. Glauzy, S., I. Andre-Schmutz, J. Larghero, S. Ezine, R. Peffault de Latour, H. Moins-Teisserenc, S. Servais, M. Robin, G. Socie, E. Clave, and A. Toubert. 2014. CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation. PloS one 9: e91492.
  10. Genin, E., D. P. Chen, S. I. Hung, P. Sekula, M. Schumacher, P. Y. Chang, S. H. Tsai, T. L. Wu, T. Bellon, R. Tamouza, C. Fortier, A. Toubert, D. Charron, A. Hovnanian, P. Wolkenstein, W. H. Chung, M. Mockenhaupt, and J. C. Roujeau. 2014. HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis. The pharmacogenomics journal 14: 281-288.
  11. Dulphy, N., G. Henry, P. Hemon, Z. Khaznadar, H. Dombret, N. Boissel, A. Bensussan, and A. Toubert. 2014. Contribution of CD39 to the immunosuppressive microenvironment of acute myeloid leukaemia at diagnosis. British journal of haematology 165: 722-725.
  12. Clave, E., A. Xhaard, C. Douay, L. Ades, J. M. Cayuela, R. Peffault de Latour, M. Robin, A. Toubert, and G. Socie. 2014. Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20: 739-742.
  13. Clave, E., C. Douay, T. Coman, M. Busson, C. Bompoint, H. Moins-Teisserenc, S. Glauzy, M. Carmagnat, N. C. Gorin, A. Toubert, and L. Garderet. 2014. Lenalidomide consolidation and maintenance therapy after autologous stem cell transplant for multiple myeloma induces persistent changes in T-cell homeostasis. Leukemia & lymphoma 55: 1788-1795.
  14. Chiron, A., J. D. Bouaziz, M. Carmagnat, R. Peffault de Latour, A. Lafaurie-Bergeron, M. Robin, A. Xhaard, A. Toubert, D. Charron, N. Guigue, G. Socie, and D. Bengoufa. 2014. Anti-Angiotensin type 1 receptor antibodies in chronic graft-versus-host disease. Transplantation 98: 470-474.
  15. Camus, M., S. Esses, B. Pariente, L. Le Bourhis, C. Douay, V. Chardiny, I. Mocan, K. Benlagha, E. Clave, A. Toubert, L. Mayer, and M. Allez. 2014. Oligoclonal expansions of mucosal T cells in Crohn’s disease predominate in NKG2D-expressing CD4 T cells. Mucosal immunology 7: 325-334.
  16. Baychelier, F., A. Achour, S. Nguyen, M. Raphael, A. Toubert, C. Besson, A. Arnoux, D. Roos-Weil, M. Marty, A. Chapelier, D. Samuel, P. Debre, and V. Vieillard. 2014. Natural killer cell deficiency in patients with non-Hodgkin lymphoma after lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
  17. Alexander, T., A. Bondanza, P. A. Muraro, R. Greco, R. Saccardi, T. Daikeler, M. Kazmi, C. Hawkey, B. P. Simoes, K. Leblanc, W. E. Fibbe, J. Moore, E. Snarski, T. Martin, F. Hiepe, A. Velardi, A. Toubert, J. A. Snowden, and D. Farge. 2014. SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking. Bone marrow transplantation.
  18. van Laar, J. M., D. Farge, J. K. Sont, K. Naraghi, Z. Marjanovic, J. Larghero, A. J. Schuerwegh, E. W. Marijt, M. C. Vonk, A. V. Schattenberg, M. Matucci-Cerinic, A. E. Voskuyl, A. A. van de Loosdrecht, T. Daikeler, I. Kotter, M. Schmalzing, T. Martin, B. Lioure, S. M. Weiner, A. Kreuter, C. Deligny, J. M. Durand, P. Emery, K. P. Machold, F. Sarrot-Reynauld, K. Warnatz, D. F. Adoue, J. Constans, H. P. Tony, N. Del Papa, A. Fassas, A. Himsel, D. Launay, A. Lo Monaco, P. Philippe, I. Quere, E. Rich, R. Westhovens, B. Griffiths, R. Saccardi, F. H. van den Hoogen, W. E. Fibbe, G. Socie, A. Gratwohl, and A. Tyndall. 2014. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. Jama 311: 2490-2498

Team 2 : “Regulation of allogeneic immune responses in renal transplantation” (team leader, N. Mooney)


  1. Asehnoune, K., P. Seguin, J. Allary, F. Feuillet, S. Lasocki, F. Cook, H. Floch, R. Chabanne, T. Geeraerts, C. Roger, P. F. Perrigault, J. L. Hanouz, A. C. Lukaszewicz, M. Biais, P. Boucheix, C. Dahyot-Fizelier, X. Capdevila, P. J. Mahe, P. Le Maguet, C. Paugam-Burtz, S. Gergaud, B. Plaud, J. M. Constantin, Y. Malledant, L. Flet, V. Sebille, and A. Roquilly. 2014. Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial. Lancet Respir Med 2: 706-716.
  2. Bine, S., A. Haziot, I. Malikova, J. Pelletier, D. Charron, J. Boucraut, N. Mooney, and C. Gelin. 2012. Alteration of CD1 expression in multiple sclerosis. Clin Exp Immunol 169: 10-16.
    3. Canet, E., E. Lengline, L. Zafrani, M. N. Peraldi, G. Socie, and E. Azoulay. 2014. Acute kidney injury in critically ill allo-HSCT recipients. Bone Marrow Transplant 49: 1121-1122.
  3. Chousterman, B., V. Gualino, A. Dohan, and D. Payen. 2014. A mysterious post-traumatic pulsatile exophthalmos. Intensive Care Med 40: 102-103.
  4. Faivre, V., A. C. Lukaszewicz, A. Alves, D. Charron, D. Payen, and A. Haziot. 2012. Human monocytes differentiate into dendritic cells subsets that induce anergic and regulatory T cells in sepsis. PLoS One 7: e47209.
  5. Gomez, H., C. Ince, D. De Backer, P. Pickkers, D. Payen, J. Hotchkiss, and J. A. Kellum. 2014. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock 41: 3-11.
  6. Gosset, C., C. Lefaucheur, and D. Glotz. 2014. New insights in antibody-mediated rejection. Curr Opin Nephrol Hypertens 23: 597-604.
  7. Knoll, G. A., M. B. Kokolo, R. Mallick, A. Beck, C. D. Buenaventura, R. Ducharme, R. Barsoum, C. Bernasconi, T. D. Blydt-Hansen, H. Ekberg, C. R. Felipe, J. Firth, L. Gallon, M. Gelens, D. Glotz, J. Gossmann, M. Guba, A. A. Morsy, R. Salgo, E. H. Scheuermann, H. Tedesco-Silva, S. Vitko, C. Watson, and D. A. Fergusson. 2014. Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data. BMJ 349: g6679.
  8. Lefaucheur, C., A. Loupy, D. Vernerey, J. P. Duong-Van-Huyen, C. Suberbielle, D. Anglicheau, J. Verine, T. Beuscart, D. Nochy, P. Bruneval, D. Charron, M. Delahousse, J. P. Empana, G. S. Hill, D. Glotz, C. Legendre, and X. Jouven. 2013. Antibody-mediated vascular rejection of kidney allografts: a population-based study. Lancet 381: 313-319.
  9. Lefaucheur, C., A. Loupy, and A. Zeevi. 2014. Complement-binding anti-HLA antibodies and kidney transplantation. N Engl J Med 370: 85-86.
  10. Legrand, M., A. Jacquemod, E. Gayat, C. Collet, V. Giraudeaux, J. M. Launay, and D. Payen. 2015. Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Intensive Care Med 41: 68-76.
  11. Legrand, M., F. Vallee, J. Mateo, and D. Payen. 2014. Influence of arterial dissolved oxygen level on venous oxygen saturation: don’t forget the PaO2! Shock 41: 510-513.
  12. Loupy, A., C. Lefaucheur, D. Vernerey, J. Chang, L. G. Hidalgo, T. Beuscart, J. Verine, O. Aubert, S. Dubleumortier, J. P. Duong van Huyen, X. Jouven, D. Glotz, C. Legendre, and P. F. Halloran. 2014. Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection. J Am Soc Nephrol 25: 2267-2277.
  13. Loupy, A., C. Lefaucheur, D. Vernerey, C. Prugger, J. P. Duong van Huyen, N. Mooney, C. Suberbielle, V. Fremeaux-Bacchi, A. Mejean, F. Desgrandchamps, D. Anglicheau, D. Nochy, D. Charron, J. P. Empana, M. Delahousse, C. Legendre, D. Glotz, G. S. Hill, A. Zeevi, and X. Jouven. 2013. Complement-binding anti-HLA antibodies and kidney-allograft survival. N Engl J Med 369: 1215-1226.
  14. Melica, G., A. L. Langlois, J. Le Goff, D. Viglietti, D. Glotz, J. M. Molina, and M. N. Peraldi. 2014. Acute enteritis associated with Coxsackievirus A19 in a kidney transplant patient. Transpl Infect Dis 16: 344-346.
  15. Payen, D. 2014. Back to basic physiological questions and consideration of fluids as drugs. Br J Anaesth 113: 732-733.
  16. Payen, D., K. Asehnoune, and H. D. Volk. 2014. Mucosal associated invariant T (MAIT) cell: a novel cellular mechanism participating in post-aggressive immunodepression. Intensive Care Med 40: 275-277.
  17. Salem, R., F. Vallee, F. Depret, J. Callebert, J. Saint Maurice, P. Marty, J. Mateo, C. Madadaki, E. Houdart, D. Bresson, S. Froelich, C. Stapf, D. Payen, and A. Mebazaa. 2014. Subarachnoid hemorrhage induces an early and reversible cardiac injury associated with catecholamine release: one-week follow-up study. Crit Care 18: 558.
  18. Shodhan, A., A. Lukaszewicz, M. Novatchkova, and J. Loidl. 2014. Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena. Genetics 198: 983-993.
  19. Taflin, C., D. Charron, D. Glotz, and N. Mooney. 2012. Regulation of the CD4+ T cell allo-immune response by endothelial cells. Hum Immunol 73: 1269-1274.
  20. Taflin, C., B. Favier, J. Baudhuin, A. Savenay, P. Hemon, A. Bensussan, D. Charron, D. Glotz, and N. Mooney. 2011. Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A 108: 2891-2896.
  21. Taflin, C., B. Favier, D. Charron, D. Glotz, and N. Mooney. 2013. Study of the allogeneic response induced by endothelial cells expressing HLA class II after lentiviral transduction. Methods Mol Biol 960: 461-472.
  22. Tambur, A. R., J. Rosati, S. Roitberg, D. Glotz, J. J. Friedewald, and J. R. Leventhal. 2014. Epitope analysis of HLA-DQ antigens: what does the antibody see? Transplantation 98: 157-166.
  23. Viglietti, D., I. Abboud, G. Hill, D. Vernerey, D. Nochy, C. Antoine, F. Fieux, M. Assayag, J. Verine, F. Gaudez, A. Loupy, D. Glotz, and C. Lefaucheur. 2014. Kidney Allograft Fibrosis After Transplantation From Uncontrolled Circulatory Death Donors. Transplantation.
  24. Viglietti, D., T. Serrato, I. Abboud, C. Antoine, E. Pillebout, M. Busson, F. Desgrandchamps, P. Meria, M. Godin, B. Hurault de Ligny, E. Thervet, C. Legendre, C. Suberbielle, J. Verine, D. Glotz, and M. N. Peraldi. 2013. Kidney graft dysfunction in simultaneous pancreas-kidney recipients after pancreas failure: analysis of early and late protocol biopsies. Clin Transplant -# E249-255.

Team 3 : “Regulation of allogeneic immune responses in renal transplantation” (team leader, N. Mooney)


  1. Warlick, E. D., R. Peffault de Latour, R. Shanley, M. Robin, N. Bejanyan, A. Xhaard, C. Brunstein, F. Sicre de Fontbrune, C. Ustun, D. J. Weisdorf, and G. Socie. 2015. Allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia: similar outcomes regardless of donor type. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 21: 357-363.
  2. Sebert, M., R. Porcher, M. Robin, L. Ades, N. Boissel, E. Raffoux, A. Xhaard, N. Dhedin, J. Larghero, C. Himberlin, A. Delmer, P. Fenaux, H. Dombret, G. Socie, and R. P. de Latour. 2015. Equivalent outcomes using reduced intensity or conventional myeloablative conditioning transplantation for patients aged 35 years and over with AML. Bone marrow transplantation 50: 74-81.
  3. Robin, M., R. Porcher, L. Ades, E. Raffoux, M. Michallet, S. Francois, J. Y. Cahn, A. Delmer, E. Wattel, S. Vigouroux, J. O. Bay, J. Cornillon, A. Huynh, S. Nguyen, M. T. Rubio, L. Vincent, N. Maillard, A. Charbonnier, R. P. de Latour, O. Reman, H. Dombret, P. Fenaux, and G. Socie. 2015. HLA-matched allogeneic stem cell transplantation improves outcome of higher risk myelodysplastic syndrome A prospective study on behalf of SFGM-TC and GFM. Leukemia.
  4. Peffault de Latour, R., V. Fremeaux-Bacchi, R. Porcher, A. Xhaard, J. Rosain, D. C. Castaneda, P. Vieira-Martins, S. Roncelin, P. Rodriguez-Otero, A. Plessier, F. Sicre de Fontbrune, S. Abbes, M. Robin, and G. Socie. 2015. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab. Blood 125: 775-783.
  5. Loschi, M., R. Porcher, R. Peffault de Latour, V. Vanneaux, M. Robin, A. Xhaard, F. Sicre de Fontebrune, J. Larghero, and G. Socie. 2015. High number of memory t cells is associated with higher risk of acute graft-versus-host disease after allogeneic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 21: 569-574.
  6. Lengline, E., S. Chevret, A. S. Moreau, F. Pene, F. Blot, J. H. Bourhis, A. Buzyn, B. Schlemmer, G. Socie, and E. Azoulay. 2015. Changes in intensive care for allogeneic hematopoietic stem cell transplant recipients. Bone marrow transplantation.
  7. Lawitschka, A., M. Faraci, I. Yaniv, P. Veys, P. Bader, J. Wachowiak, G. Socie, M. D. Aljurf, M. Arat, J. J. Boelens, R. Duarte, A. Tichelli, and C. Peters. 2015. Paediatric reduced intensity conditioning: analysis of
  8. Socie, G. 2014. Disease severity in chronic graft-versus-host disease: doctors’ gut feeling versus biostatistics? Haematologica 99: 1534-1536.
  9. Servais, S., R. Porcher, A. Xhaard, M. Robin, E. Masson, J. Larghero, P. Ribaud, N. Dhedin, S. Abbes, F. Sicre, G. Socie, and R. Peffault de Latour. 2014. Pre-transplant prognostic factors of long-term survival after allogeneic peripheral blood stem cell transplantation with matched related/unrelated donors. Haematologica 99: 519-526.
  10. Servais, S., E. Lengline, R. Porcher, M. Carmagnat, R. Peffault de Latour, M. Robin, F. Sicre de Fontebrune, E. Clave, G. Maki, C. Granier, A. Xhaard, N. Dhedin, J. M. Molina, A. Toubert, H. Moins-Teisserenc, and G. Socie. 2014. Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20: 507-517.
  11. chrezenmeier, H., P. Muus, G. Socie, J. Szer, A. Urbano-Ispizua, J. P. Maciejewski, R. A. Brodsky, M. Bessler, Y. Kanakura, W. Rosse, G. Khursigara, C. Bedrosian, and P. Hillmen. 2014. Baseline characteristics and disease burden in patients in the International Paroxysmal Nocturnal Hemoglobinuria Registry. Haematologica 99: 922-929.
  12. Schlemmer, F., S. Chevret, G. Lorillon, C. De Bazelaire, R. Peffault de Latour, V. Meignin, M. Michallet, E. Hermet, B. Wyplosz, V. Houdouin, S. Marchand-Adam, G. Socie, A. Tazi, and A. Bergeron. 2014. Late-onset noninfectious interstitial lung disease after allogeneic hematopoietic stem cell transplantation. Respiratory medicine 108: 1525-1533.
  13. Ruutu, T., A. Gratwohl, T. de Witte, B. Afanasyev, J. Apperley, A. Bacigalupo, F. Dazzi, P. Dreger, R. Duarte, J. Finke, L. Garderet, H. Greinix, E. Holler, N. Kroger, A. Lawitschka, M. Mohty, A. Nagler, J. Passweg, O. Ringden, G. Socie, J. Sierra, A. Sureda, W. Wiktor-Jedrzejczak, A. Madrigal, and D. Niederwieser. 2014. Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice. Bone marrow transplantation 49: 168-173.
  14. Rondelli, T., A. M. Risitano, R. Peffault de Latour, M. Sica, B. Peruzzi, P. Ricci, W. Barcellini, A. P. Iori, C. Boschetti, V. Valle, V. Fremeaux-Bacchi, M. De Angioletti, G. Socie, L. Luzzatto, and R. Notaro. 2014. Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria. Haematologica 99: 262-266.
  15. Meunier, M., A. C. Manez, A. Xhaard, R. Peffault de Latour, F. S. de Fontbrune, N. Dhedin, G. Socie, and M. Robin. 2014. Late donor bone marrow failure after allogeneic hematopoietic stem cell transplantation. Transplantation 97: e75-77.
  16. de Masson, A., M. Beylot-Barry, J. D. Bouaziz, R. Peffault de Latour, F. Aubin, S. Garciaz, M. d’Incan, O. Dereure, S. Dalle, A. Dompmartin, F. Suarez, M. Battistella, M. D. Vignon-Pennamen, J. Rivet, H. Adamski, P. Brice, S. Francois, S. Lissandre, P. Turlure, E. Wierzbicka-Hainaut, E. Brissot, R. Dulery, S. Servais, A. Ravinet, R. Tabrizi, S. Ingen-Housz-Oro, P. Joly, G. Socie, and M. Bagot. 2014. Allogeneic stem cell transplantation for advanced cutaneous T-cell lymphomas: a study from the French Society of Bone Marrow Transplantation and French Study Group on Cutaneous Lymphomas. Haematologica 99: 527-534.
  17. Battistella, M., W. Cuccuini, M. Elbouchtaoui, C. Leboeuf, L. F. Plassa, F. Bouhidel, A. Rigolet, V. Meignin, G. Socie, P. Ratajczak, and A. Janin. 2014. p53 phosphorylation and TP53 copy-number alterations in chronic graft-versus-host oral lichen preceding squamous cell carcinoma. The Journal of investigative dermatology 134: 864-867.
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