Team 1 « Lymphocyte differentiation and homeostasis in allo- and autoimmunity »

Tuesday 5 May 2015

Team leader


Titre : Professeur des Universités, Praticien hospitalier
Nom : TOUBERT
Prénom : Antoine
Tel : 0142494897
Mail : antoine.toubert@univ-paris-diderot.fr
Research Theme
List of members
Publications

Research Theme

« Lymphocyte differentiation and homeostasis in allo- and autoimmunity »
The overall goal of this team will be to evaluate how different pathological contexts (allo-HSCT, hematological malignancies, autoimmunity) may impact the mechanisms of physiological lymphocyte differentiation (T, NK, iNKT) and participate in functional impairment in the disease process: delay of immune recovery in alloHSCT, defective immune responses in leukemias, unbalanced reactivity in autoimmunity (inflammatory bowel diseases).

List of members

Lymphocyte differentiation and homeostasis in allo- and autoimmunity

TOUBERT Antoine (PPH, APHP)
CAIGNARD Anne (DR2 INSERM)
BENLAGHA Kamel (DR2 INSERM)
DULPHY Nicolas (MCU-PH, APHP)
MOINS Hélène (MCU-PH, P7 APHP)
REA Delphine (PH, APHP)
FARGE Dominique (PPH, APHP)
JORGE CORDEIRA Debora (AHU, APHP)
CLAVE Emmanuel (IE, P7)
DOUAY Dorinne (IE, P7)
HENRY Guylaine (TECH, APHP)
HOMYRDYA Laurence (TECH, APHP)
FOURNIER Isabelle (TECH, APHP)
FELIX Joanna (Doctorante, P7)
SIHMAN Li (Doctorante, P7)
JOSEPH Claudine (Doctorante, P7)
PERROT Floriane (M2, Paris XIi)
OULD-CHICKH Zohra (CDD INSERM) laverie

maladies inflammatoires du tube digestif

ALLEZ Matthieu (PPH, APHP)
LE BOURHIS Lionel (CR1, INSERM)
CHARDINY Victor (TECH, INSERM)

«Immunogénétique»

TAMOUZA Ryad (PH, APHP)
MARZAIS François (TECH, APHP)
FORTIER Catherine (TECH, APHP)
BOUKOUACI Wahid (Post doct, Privé)
BENNABI Meriem (Doctorante p7, Privé)

Publications


  1. Moins-Teisserenc, H., M. Daubord, E. Clave, C. Douay, J. Felix, A. Marie-Cardine, C. Ram-Wolff, G. Maki, K. Beldjord, L. Homyrda, L. Michel, A. Bensussan, A. Toubert, and M. Bagot. 2015. CD158k Is a Reliable Marker for Diagnosis of Sezary Syndrome and Reveals an Unprecedented Heterogeneity of Circulating Malignant Cells. The Journal of investigative dermatology 135: 247-257.
  2. Itzykson, R., M. Robin, H. Moins-Teisserenc, M. Delord, M. Busson, A. Xhaard, F. S. de Fontebrune, R. Peffault de Latour, A. Toubert, and G. Socie. 2015. Cytomegalovirus shapes long-term immune reconstitution after allogeneic stem cell transplantation. Haematologica 100: 114-123.
  3. Yap, M., F. Boeffard, E. Clave, A. Pallier, R. Danger, M. Giral, J. Dantal, Y. Foucher, C. Guillot-Gueguen, A. Toubert, J. P. Soulillou, S. Brouard, and N. Degauque. 2014. Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction. Journal of the American Society of Nephrology : JASN 25: 1856-1868.
  4. Xhaard, A., H. Moins-Teisserenc, M. Busson, M. Robin, P. Ribaud, N. Dhedin, S. Abbes, M. Carmagnat, V. D. Kheav, G. Maki, R. Peffault de Latour, A. Toubert, and G. Socie. 2014. Reconstitution of regulatory T-cell subsets after allogeneic hematopoietic SCT. Bone marrow transplantation 49: 1089-1092.
  5. Servais, S., E. Lengline, R. Porcher, M. Carmagnat, R. Peffault de Latour, M. Robin, F. Sicre de Fontebrune, E. Clave, G. Maki, C. Granier, A. Xhaard, N. Dhedin, J. M. Molina, A. Toubert, H. Moins-Teisserenc, and G. Socie. 2014. Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20: 507-517.
  6. Kheav, V. D., M. Busson, C. Scieux, R. Peffault de Latour, G. Maki, P. Haas, M. C. Mazeron, M. Carmagnat, E. Masson, A. Xhaard, M. Robin, P. Ribaud, N. Dulphy, P. Loiseau, D. Charron, G. Socie, A. Toubert, and H. Moins-Teisserenc. 2014. Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation. Haematologica 99: 1860-1867.
  7. Khaznadar, Z., G. Henry, N. Setterblad, S. Agaugue, E. Raffoux, N. Boissel, H. Dombret, A. Toubert, and N. Dulphy. 2014. Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse. European journal of immunology 44: 3068-3080.
  8. Glauzy, S., J. Soret, I. Fournier, C. Douay, H. Moins-Teisserenc, R. Peffault de Latour, G. Maki, M. Robin, G. Socie, A. Toubert, and E. Clave. 2014. Impact of acute and chronic graft-versus-host disease on human B-cell generation and replication. Blood 124: 2459-2462.
  9. Glauzy, S., I. Andre-Schmutz, J. Larghero, S. Ezine, R. Peffault de Latour, H. Moins-Teisserenc, S. Servais, M. Robin, G. Socie, E. Clave, and A. Toubert. 2014. CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation. PloS one 9: e91492.
  10. Genin, E., D. P. Chen, S. I. Hung, P. Sekula, M. Schumacher, P. Y. Chang, S. H. Tsai, T. L. Wu, T. Bellon, R. Tamouza, C. Fortier, A. Toubert, D. Charron, A. Hovnanian, P. Wolkenstein, W. H. Chung, M. Mockenhaupt, and J. C. Roujeau. 2014. HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis. The pharmacogenomics journal 14: 281-288.
  11. Dulphy, N., G. Henry, P. Hemon, Z. Khaznadar, H. Dombret, N. Boissel, A. Bensussan, and A. Toubert. 2014. Contribution of CD39 to the immunosuppressive microenvironment of acute myeloid leukaemia at diagnosis. British journal of haematology 165: 722-725.
  12. Clave, E., A. Xhaard, C. Douay, L. Ades, J. M. Cayuela, R. Peffault de Latour, M. Robin, A. Toubert, and G. Socie. 2014. Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20: 739-742.
  13. Clave, E., C. Douay, T. Coman, M. Busson, C. Bompoint, H. Moins-Teisserenc, S. Glauzy, M. Carmagnat, N. C. Gorin, A. Toubert, and L. Garderet. 2014. Lenalidomide consolidation and maintenance therapy after autologous stem cell transplant for multiple myeloma induces persistent changes in T-cell homeostasis. Leukemia & lymphoma 55: 1788-1795.
  14. Chiron, A., J. D. Bouaziz, M. Carmagnat, R. Peffault de Latour, A. Lafaurie-Bergeron, M. Robin, A. Xhaard, A. Toubert, D. Charron, N. Guigue, G. Socie, and D. Bengoufa. 2014. Anti-Angiotensin type 1 receptor antibodies in chronic graft-versus-host disease. Transplantation 98: 470-474.
  15. Camus, M., S. Esses, B. Pariente, L. Le Bourhis, C. Douay, V. Chardiny, I. Mocan, K. Benlagha, E. Clave, A. Toubert, L. Mayer, and M. Allez. 2014. Oligoclonal expansions of mucosal T cells in Crohn’s disease predominate in NKG2D-expressing CD4 T cells. Mucosal immunology 7: 325-334.
  16. Baychelier, F., A. Achour, S. Nguyen, M. Raphael, A. Toubert, C. Besson, A. Arnoux, D. Roos-Weil, M. Marty, A. Chapelier, D. Samuel, P. Debre, and V. Vieillard. 2014. Natural killer cell deficiency in patients with non-Hodgkin lymphoma after lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
  17. Alexander, T., A. Bondanza, P. A. Muraro, R. Greco, R. Saccardi, T. Daikeler, M. Kazmi, C. Hawkey, B. P. Simoes, K. Leblanc, W. E. Fibbe, J. Moore, E. Snarski, T. Martin, F. Hiepe, A. Velardi, A. Toubert, J. A. Snowden, and D. Farge. 2014. SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking. Bone marrow transplantation.
  18. van Laar, J. M., D. Farge, J. K. Sont, K. Naraghi, Z. Marjanovic, J. Larghero, A. J. Schuerwegh, E. W. Marijt, M. C. Vonk, A. V. Schattenberg, M. Matucci-Cerinic, A. E. Voskuyl, A. A. van de Loosdrecht, T. Daikeler, I. Kotter, M. Schmalzing, T. Martin, B. Lioure, S. M. Weiner, A. Kreuter, C. Deligny, J. M. Durand, P. Emery, K. P. Machold, F. Sarrot-Reynauld, K. Warnatz, D. F. Adoue, J. Constans, H. P. Tony, N. Del Papa, A. Fassas, A. Himsel, D. Launay, A. Lo Monaco, P. Philippe, I. Quere, E. Rich, R. Westhovens, B. Griffiths, R. Saccardi, F. H. van den Hoogen, W. E. Fibbe, G. Socie, A. Gratwohl, and A. Tyndall. 2014. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. Jama 311: 2490-2498

Navigation

in the same section...

  • Team 1 « Lymphocyte differentiation and homeostasis in allo- and autoimmunity »